• A recent study indicates a rise in emergency room visits related to gastrointestinal issues caused by semaglutide, the active ingredient in Ozempic and Wegovy.
• Cosmetic side effects like 'Ozempic face,' 'Ozempic mouth,' and 'Ozempic feet' are being reported, resulting from rapid weight loss and loss of facial fat.
• Experts recommend dietary adjustments, resistance training, and a slower pace of weight loss to minimize side effects, emphasizing the importance of medical supervision.

The increasing use of GLP-1 medications like Ozempic and Wegovy for weight loss has been accompanied by reports of significant side effects. A recent study highlighted a rise in emergency room visits due to gastrointestinal complications associated with these drugs. Additionally, cosmetic side effects, such as facial wrinkling and sagging skin, termed 'Ozempic face,' are drawing attention. Experts emphasize the need for medical supervision, dietary adjustments, and exercise to mitigate these effects and ensure safe weight loss.

• What: Reports of increased emergency room visits and cosmetic side effects, like 'Ozempic face', associated with GLP-1 medications used for weight loss.
• Who: Individuals using GLP-1 medications such as Ozempic, Wegovy, Zepbound, and Mounjaro; medical professionals; celebrities.
• When: Reports primarily focus on the period between 2022 and 2024, with emphasis on recent observations and study findings.
• Where: United States, with mentions of studies conducted by the Centers for Disease Control and Prevention and experts from various medical centers.

The reports reveal a complex picture of GLP-1 medication use. While effective for weight loss and managing diabetes, these drugs are linked to potentially serious side effects requiring emergency medical care. The cosmetic side effects also raise concerns about the impact of rapid weight loss on physical appearance. Experts stress the importance of a holistic approach, combining medication with lifestyle changes and medical supervision to minimize risks and optimize health outcomes. The increasing prevalence of GLP-1 medication usage warrants further research and comprehensive patient education.

The safety and efficacy profile of Ozempic has been evaluated in clinical studies involving more than patients. The most commonly reported side effects were gastrointestinal, including nausea, vomiting, diarrhea, stomach (abdominal) pain, and constipation. The known risks associated with use of Ozempic are reflected in the FDA-approved product labeling.

We found that it’s very infrequent that semaglutide leads to very serious adverse events that would land a patient in the hospital, but that they do occur.

Many users of Ozempic who I know report noticeable volume loss in the face, which can result in the formation of fine lines, wrinkles, sagging skin, and jowls around the mouth

GLP-1 medications represent a significant advancement in managing weight loss and diabetes, yet their use demands a comprehensive understanding of both benefits and risks. Beyond the well-established advantages in glycemic control and weight reduction, emerging research indicates potential benefits in cognitive and behavioral health, including reduced risks of dementia, Alzheimer's disease, addiction, and certain psychiatric disorders. However, these "miracle drugs" are also associated with a spectrum of adverse effects, ranging from common gastrointestinal issues like nausea, vomiting, and diarrhea to more severe complications such as pancreatitis, kidney problems, gastroparesis, and bowel obstruction. Increased emergency room visits and cosmetic concerns, including sagging skin, facial volume loss, and "Ozempic mouth," further underscore the need for careful patient monitoring and proactive mitigation strategies. A balanced approach is crucial, integrating lifestyle adjustments such as healthy eating, regular exercise, and stress management with medical oversight to maximize efficacy and minimize harm. Individualized treatment plans, incorporating dietary guidance, physical activity, and mental health support, are essential for sustainable weight loss and overall well-being. Moreover, transparent communication regarding potential side effects, the importance of long-term therapy, and the possibility of weight regain after discontinuation is paramount. Further research into the long-term effects of GLP-1s on various body systems, including the brain, pancreas, and kidneys, is necessary to refine treatment protocols and ensure patient safety. As the use of GLP-1 medications expands, a holistic approach that addresses both the physiological and psychological aspects of obesity and diabetes is vital for achieving optimal outcomes and improving the quality of life for individuals using these medications.